METHYLATION status testing with Histamine Whole blood
Whole Blood histamine levels are used as a marker for methylation status. Histamine, in its whole blood form, is utilized as an accurate marker for under methylation or over methylation.
Elevated whole blood histamine levels indicate under-methylation. Review of symptoms and medical history can bolster the diagnosis. For example, most under-methylated persons exhibit seasonal allergies, perfectionism, strong wills, slenderness, OCD tendencies, high libido, depression.
Low whole blood histamine levels indicate over-methylation. Persons who are over-methylated generally exhibit high anxiety, panic disorders, absence of seasonal allergies, presence of food/chemical sensitivities, dry eyes, low perspiration, artistic/music interests/abilities, intolerance to Prozac and other SSRI’s, etc.
Conditions associated with under-methylation are: Anorexia, Bulimia, shopping/gambling disorders, depression, schizo-affective disorder, delusions, oppositional-defiant disorder, OCD.
Conditions associated with over-methylation are: Anxiety/Panic disorders, anxious depression, hyperactivity, learning disabilities, low motivation, paranoid schizophrenia, hallucinations. (Oct 3, 2003) Most persons with depression, oppositional defiant disorder, OCD, bipolar disorder, or schizophrenia exhibit a genetic abnormality in methylation which appears to be central to their illness. Carl Pfeiffer, MD, PhD of Princeton, NJ was a pioneer in this field. (Oct 3, 2003)